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Bone marrow failure and myelofibrosis in a case of PVP storage disease
Author(s) -
Dunn Po,
Kuo Tsengtong,
Shih LeeYung,
Wang PoNan,
Sun ChienFeng,
Chang Ming J.W.
Publication year - 1998
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199801)57:1<68::aid-ajh12>3.0.co;2-5
Subject(s) - medicine , histiocyte , bone marrow , infiltration (hvac) , pathology , myelofibrosis , arthritis , surgery , physics , thermodynamics
“PVP storage disease” is a disorder occurring in patients who have received high molecular weight polyvinylpyrrolidone (PVP), which cannot be excreted from the body. These large polymers deposit in the histiocytes and cause proliferation and infiltration of histiocytes in the reticuloendothelial system. There was usually no significant damage to these organs except that prolonged administration might cause bone destruction, skin lesions, arthritis, and polyneuropathy. We describe a patient who had received a large amount of PVP‐containing solution for years. Severe bone marrow failure with extensive infiltration of bone marrow by foamy histiocytes occurred later. In addition, she suffered from multiple pathological fractures with spinal cord compression and arthritis of bilateral knee joints. Am. J. Hematol. 57:68–71, 1998. © 1998 Wiley‐Liss, Inc.