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Human umbilical cord blood myeloid progenitor cells are relatively chemoresistant: A potential model for autologous transplantations in HIV‐infected newborns
Author(s) -
Toren Amos,
Einat Michal,
Fabian Ina,
Nagler Ar
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199711)56:3<161::aid-ajh5>3.0.co;2-w
Subject(s) - umbilical cord , stem cell , progenitor cell , immunology , medicine , myeloid , cord blood , transplantation , cytarabine , bone marrow , virology , cancer research , biology , myeloid leukemia , genetics
Vertical transmission from mother to child occurs in 15–39% of women infected with the human immunodeficiency virus (HIV). Stem cell transplantation has recently been suggested as a potential therapy for patients with HIV infection. We have examined the possible advantages of human cord blood (HUCB) stem cells over bone marrow (BM) stem cells in the treatment of HIV‐infected newborns. HUCB myeloid progenitors were found to be statistically more resistant to interferon‐α (IFN‐α), cytarabine (ARA‐C), and eilatin than BM myeloid progenitor cells grown with IL‐3 ( P < 0.05). HUCB treated with IFN‐α, ARA‐C, and eilatin demonstrated a significantly higher capacity for self‐renewal manifested by delta assay following 7 days in liquid culture. We, therefore, suggest that HUCB purged by anti‐HIV drugs may be a source for autologous transplantation in HIV‐infected newborns. Am. J. Hematol. 56:161–167, 1997. © 1997 Wiley‐Liss, Inc.