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Antibody studies in a patient with acute thrombocytopenia following infusion of plasma containing anti‐PI A1
Author(s) -
BrunnerBolliger S.,
Kiefel V.,
Horber F. F.,
Nydegger U. E.,
Berchtold P.
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199710)56:2<119::aid-ajh8>3.0.co;2-1
Subject(s) - antibody , medicine , immunology , isoantibodies
Immune thrombocytopenia due to passive transfer of anti‐PI A1 alloantibody has been noted as a rare but potentially dangerous complication of plasma transfusions. We report a patient with a preoperative platelet count of 241 × 10 9 /l who developed severe thrombocytopenia within 2 hr following transfusion of 2 U of fresh frozen plasma. The plasma donor was found to be a PI A1 ‐negative woman. The platelet count of the PI A1 ‐positive patient recovered within 7 days to normal values. In the frozen plasma, excessive antibody binding to GPIIb‐IIIa on the recipient's platelets was detected. The antibody was shown to have anti‐PI A1 ‐specificity. Only 40 min after transfusion of the frozen plasma, no antibody was detected in the plasma of the recipient. This case suggests that passively administered anti‐PI A1 alloantibody is immediately adsorbed onto the recipient's platelets and thus removed from circulation. Am. J. Hematol. 56:119–121, 1997. © 1997 Wiley‐Liss, Inc.