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Increased tissue factor pathway inhibitor in patients with acute myocardial infarction
Author(s) -
Kamikura Yuko,
Wada Hideo,
Yamada Atsushi,
Shimura Minori,
Hiyoyama Katsuyo,
Shiku Hiroshi,
Tanigawa Motoaki,
Nishikawa Hideo,
Yamada Norikazu,
Isaka Naoki,
Nakano Takeshi,
Kumeda Kousuke,
Kato Hisao
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199707)55:4<183::aid-ajh3>3.0.co;2-o
Subject(s) - tissue factor pathway inhibitor , medicine , thrombosis , myocardial infarction , cardiology , fibrinolysis , plasminogen activator , deep vein , pulmonary embolism , fibrin , d dimer , tissue plasminogen activator , tissue factor , gastroenterology , coagulation , immunology
We examined hemostatic abnormalities in 23 patients with acute myocardial infarction (AMI), 10 with pulmonary embolism (PE), and 10 with deep vein thrombosis (DVT). At the onset of AMI, plasma levels of tissue‐type plasminogen activator (t‐PA), PA inhibitor‐I (PAI‐I), fibrin‐D‐dimer, thrombin‐antithrombin complex (TAT), and plasmin‐plasmin inhibitor complex (PPIC) were significantly increased. Both the plasma total TFPI and free‐TFPI levels in the AMI patients were significantly higher than those in the healthy volunteers, PE patients, and DVT patients. There was no significant difference in total TFPI or free‐TFPI among patients with PE, those with DVT, and healthy volunteers. One hour after percutaneous transluminal coronary angioplasty (PTCA) in the AMI group, the total TFPI level was further increased, and it was significantly reduced 24 hr after PTCA, to a level similar to that in healthy volunteers. Free‐TFPI showed a pattern similar to that of total TFPI. The ratio of free‐TFPI/total TFPI was highest 1 hr after PTCA. Increased TFPI in AMI patients might be released from ischemic tissues. Am. J. Hematol. 55:183–187, 1997. © 1997 Wiley‐Liss, Inc.