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Von Willebrand factor and soluble E‐selectin in hyperlipidaemia: Relationship to lipids and vascular disease
Author(s) -
Blann Andrew D.,
Davis Alison,
Miller J. Paul,
McCollum Charles N.
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199705)55:1<15::aid-ajh3>3.0.co;2-6
Subject(s) - von willebrand factor , medicine , endocrinology , vascular disease , risk factor , cholesterol , blood lipids , triglyceride , platelet
Our objective was to determine whether endothelial cell products von Willebrand factor and soluble E‐selectin are related to serum lipids, lipoprotein (a), and vascular disease in patients with hyperlipidaemia. In order to achieve our aim, blood samples were obtained for four experiments from 1) 160 patients (49 with symptomatic vascular disease) with hypercholesterolaemia and an equal number of age and sex matched controls; 2) 31 patients who were studied serially before and after successful resolution of their hypercholesterolaemia; 3) 15 patients with hypertriglyceridaemia; and 4) 20 controls, half of whom consumed a lipid‐rich breakfast. von Willebrand factor and soluble E‐selectin were measured by enzyme linked immunosorbent assay (ELISA) using commercial reagents. In experiment (1) von Willebrand factor was increased in the patients with hypercholesterolaemia ( P =0.0077) and was higher still in patients with vascular disease (P<0.0001). Soluble E‐selectin was not influenced by hypercholesterolaemia or vascular disease. The correlation of von Willebrand factor with total and LDL cholesterol (both P <0.001) remained after both age and blood pressure were controlled. Experiment (2) showed that serial studies in patients over an average of 7 months a reduction in total cholesterol was associated with a reduction in von Willebrand factor (r=0.51, P =0.002). Experiment (3) demonstrated that von Willebrand factor was not increased in patients with hypertriglyceridaemia (median 8.9 mmol/L), and in experiment (4) a lipid‐rich breakfast taken by fasted, healthy controls produced an increase in serum triglycerides ( P <0.01) but did not influence von Willebrand factor over an 8 hour period. We conclude that von Willebrand factor, but not soluble E‐selectin, is raised in hypercholesterolaemia and therefore may be a potential indicator of endothelial cell physiology in subjects with, or at risk of, atherosclerotic vascular disease. Am. J. Hematol. 55:15‐23, 1997. © 1997 Wiley‐Liss, Inc.