Premium
Treatment of refractory large granular lymphocytic leukemia with 2‐chlorodeoxyadenosine
Author(s) -
Edelman Martin J.,
O'Donnell Robert T.,
Meadows Ivan
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199704)54:4<329::aid-ajh13>3.0.co;2-6
Subject(s) - pancytopenia , refractory (planetary science) , methotrexate , medicine , prednisone , leukemia , cd8 , acute lymphocytic leukemia , gastroenterology , hairy cell leukemia , immunology , bone marrow , immune system , biology , lymphoblastic leukemia , astrobiology
A 50‐year‐old man with large granular lymphocytic leukemia (CD3+, CD8+) complicated by severe pancytopenia and life‐threatening infections refractory to therapy with prednisone, methotrexate, cyclosporine, and G‐CSF is described. Treatment with two cycles of 2‐chlorodeoxyadenosine (2‐CDA) at 0.1 mg/kg by continuous intravenous infusion for 7 days each cycle resulted in resolution of cytopenias and clearance of leukemic cells. T‐cell receptor gene rearrangement, initially present, was not detectable after therapy with 2‐CDA. The rapid and complete response to 2‐CDA after unsuccessful attempts with prior therapy suggests that 2‐CDA should be considered for initial treatment of this disorder. Am. J. Hematol. 54:329–331, 1997. © 1997 Wiley‐Liss, Inc.