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Multicentric Castleman's disease with an increased serum level of macrophage colony‐stimulating factor
Author(s) -
Lee Muneyasu,
Hirokawa Makoto,
Matuoka Satoru,
Hasegawa Hitoshi,
Nanjo Hiroshi,
Matsushima Takashi,
Imatani Hideo,
Miura Akira B.
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199704)54:4<321::aid-ajh11>3.0.co;2-e
Subject(s) - medicine , macrophage colony stimulating factor , pathological , chemotherapy , tumor necrosis factor alpha , macrophage , disease , interleukin 6 , pathology , immunology , endocrinology , cytokine , biology , biochemistry , in vitro
We describe a 74‐year‐old patient with multicentric Castleman's disease (MCD) whose serum macrophage colony‐stimulating factor level was elevated. Serum levels of tumor necrosis factor‐α and interleukin 6 were also elevated at presentation, and they returned to normal levels after chemotherapy. Although the total serum cholesterol level was below normal on admission, it increased after chemotherapy. These results suggest that the activation of monocytes or macrophages may be involved in certain pathological phenomena in MCD. Am. J. Hematol. 54: 321–323, 1997. © 1997 Wiley‐Liss, Inc.