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Beta‐globin haplotypes from blood spots for follow‐up of newborn hemoglobinopathy screening
Author(s) -
Hiti Alan L.,
Zeng Licheng,
Xiang Qing,
Lorey Fred W.,
Powars Darleen R.
Publication year - 1997
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199701)54:1<76::aid-ajh12>3.0.co;2-8
Subject(s) - hemoglobinopathy , medicine , haplotype , globin , beta (programming language) , beta thalassaemia , beta thalassemia , thalassemia , pediatrics , hemoglobin , hemolytic anemia , genetics , biology , genotype , gene , computer science , programming language
The inheritance of sickle‐cell anemia upon the background of the major β‐globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identification of β‐globin haplotypes in individuals with sickle‐cell anemia may be a clinically useful prognostic factor for severity of disease expression. This report describes the use of whole‐blood spots on filter papers from newborn hemoglobinopathy screening for β‐globin gene cluster haplotyping by the polymerase chain reaction. Am. J. Hematol. 54:76–78, 1997. © 1997 Wiley‐Liss, Inc.