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Inhibition of marrow CFU‐E colony formation from human immunodeficiency virus‐infected patients by β‐ and γ‐interferon
Author(s) -
Dallalio Gail,
North Melissa,
Means Robert T.
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199610)53:2<118::aid-ajh10>3.0.co;2-b
Subject(s) - immunology , cytokine , interferon , virology , virus , biology , bone marrow , in vitro , colony forming unit , human immunodeficiency virus (hiv) , cfu gm , progenitor cell , stem cell , biochemistry , genetics , bacteria
Increased production of cytokines such as β‐interferon (IFN) and γ‐IFN may contribute to the anemia frequently observed in patients with human immunodeficiency virus (HIV) infection. The hypothesis that HIV infection might enhance the susceptibility of erythroid progenitors to cytokine‐mediated inhibition was evaluated by comparing the effects of β‐ and γ‐IFN on in vitro colony formation by marrow erythroid colony‐forming units (CFU‐E) from HIV patients, normal volunteers, and anemic non‐HIV‐infected individuals. CFU‐E colony formation from HIV patients was not significantly different from controls, and the degree of inhibition by IFN did not differ among patient subsets. HIV infection does not appear to impair baseline CFU‐E colony formation, nor does it appear to enhance the susceptibility of CFU‐E to suppression by cytokines. © 1996 Wiley‐Liss, Inc.