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Factor V Q 506 mutation in children with thrombosis
Author(s) -
Gurgey Aytemiz,
Mesci Lutfiye,
Renda Yavuz,
Olcay Lale,
Kocak Nurten,
Erdem Gulsen
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199609)53:1<37::aid-ajh8>3.0.co;2-6
Subject(s) - mutation , thrombosis , medicine , genetics , pediatrics , biology , gene
The factor V Leiden mutation in 12 children with thrombosis and in 20 controls was investigated. Five heterozygous individuals and 1 homozygous individual among the cases with thrombosis and 1 heterozygous individual among controls were found. Central nervous system thromboses were increased in children with the factor V mutation, associated with protein S deficiency. © 1996 Wiley‐Liss, Inc.