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Different adhesion types and active sensitivity of platelet subpopulations
Author(s) -
Zhao B.,
Filler T. J.,
Rickert C. H.,
Liu J. F.,
SkhollEngberts A. D.,
Gurevich V.
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199608)52:4<322::aid-ajh15>3.0.co;2-f
Subject(s) - platelet , adenosine , thrombin , adhesion , adenosine diphosphate , chemistry , biophysics , biochemistry , medicine , biology , platelet aggregation , organic chemistry
Two different adhesion patterns of blood platelets with different sensitivity to adenosine were demonstrated by means of reflection contrast microscopy with consecutive image analysis and cell affinity chromatography. High‐performance liquid chromatography revealed that thrombin‐induced serotonin release of adenosine‐sensitive platelets was lower than that of adenosine‐resistant cells. Our results indicate platelet heterogeneity and suggest that the platelets with lower adenosine sensitivity may be actively involved in the early interaction between platelets and injured endothelium. © 1996 Wiley‐Liss, Inc.