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Influence of purified apoprotein E on platelet activation induced by serotonin
Author(s) -
Pfennig Olaf,
Zhao Bin,
Dierichs Rolf
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199608)52:4<319::aid-ajh14>3.0.co;2-8
Subject(s) - platelet , serotonin , platelet activation , agonist , endocrinology , medicine , chemistry , platelet aggregation , pharmacology , receptor
Serotonin induces platelet activation. Purified apoprotein E of 300 μg/ml prevented morphological alterations of blood platelets stimulated with serotonin (5 μM). Lower concentrated apoprotein E showed no such clear effects. These findings suggest that apoprotein E may liter atherosclerosis by suppressing agonist‐induced platelet activation. © 1996 Wiley‐Liss, Inc.