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Lymphoblastic transformation of chronic myelomonocytic leukemia in an infant
Author(s) -
Yamamoto Masuji,
Nakagawa Makiko,
Ichimura Noriko,
Ohtsuki Fumiko,
Ohtsuka Yoshitoshi,
Tsujino Yoshiaki,
Tanaka Aiichiro,
Kamiya Takashi,
Wada Hiroyoshi
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199607)52:3<212::aid-ajh14>3.0.co;2-h
Subject(s) - cd33 , chronic myelomonocytic leukemia , myeloid , immunology , antigen , cd19 , induced pluripotent stem cell , medicine , juvenile myelomonocytic leukemia , leukemia , stem cell , biology , cancer research , bone marrow , myelodysplastic syndromes , haematopoiesis , genetics , gene , cd34 , embryonic stem cell
A 10‐month‐old infant with chronic myelomonocytic leukemia (CMML) of 5 months' duration, who had been treated only with transfusion, displayed leukemic transformation characterized by lymphoid morphology, PAS positivity, and myeloperoxidase negativity. Surface marker analysis of blast cells revealed expression of lymphoid‐associated antigens (CD10 and CD19) but not myeloid‐associated antigens (CD13, CD14, and CD33). These findings suggest that some cases of infantile CMML are clonal disorders arising in a pluripotent stem cell that can also differentiate along the lymphoid cell lineage. © 1996 Wiley‐Liss, Inc.