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HyperCVAD for VAD‐resistant multiple myeloma
Author(s) -
Dimopoulos Meletios A.,
Weber Donna,
Kantarjian Hagop,
Delasalle Kay B.,
Alexanian Raymond
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199606)52:2<77::aid-ajh2>3.0.co;2-2
Subject(s) - medicine , cyclophosphamide , multiple myeloma , surgery , chemotherapy , gastroenterology
Abstract More effective and safer regimens are needed for patients who have advanced multiple myeloma resistant to or relapsing despite prior treatment with alkylating agents and VAD. We treated 58 such patients using the combination of twice daily cyclophosphamide (total dose 1.8 g/m 2 ) and VAD (hyperCVAD). Treatment was given to outpatients followed by G‐CSF at 5 μg/kg/d until granulocyte recovery. Twenty‐three patients responded (40%), with a median duration of granulocyte depression to less than 500/μl of 4 days and a mortality rate of 2%. The median survival time for all patients was 15 months, and the median remission time of responding patients was 8 months. Patients who had low LDH, low B 2 M, or primary resistant disease lived significantly longer than patients without these features. The combination of fractionated cyclophosphamide and VAD provided an effective and safe rescue treatment for many patients who had advanced myeloma resistant to standard therapies. © 1996 Wiley‐Liss, Inc.