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Negligible synergistic effect of β 2 ‐glycoprotein I on the reactivity of antioxidized low‐density lipoprotein antibody to oxidized low‐density lipoprotein
Author(s) -
Matsuda Juzo,
Gotoh Moritaka,
Kawasugi Kazuo,
Gohchi Kengo,
Tsukamoto Miyo,
Saitoh Noriko
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199606)52:2<114::aid-ajh8>3.0.co;2-x
Subject(s) - antibody , glycoprotein , lipoprotein , chemistry , lupus anticoagulant , low density lipoprotein , phospholipid , antigen , reactivity (psychology) , immunology , lupus erythematosus , medicine , endocrinology , biochemistry , cholesterol , pathology , membrane , alternative medicine
We conducted this study to investigate whether antioxidized low‐density lipoprotein (a‐oxLDL) is an antibody to cryptic and/or neo‐antigen on β 2 ‐glycoprotein I (GPI), which is introduced by binding to anionic phospholipid, similar to that of GPI‐dependent anticardiolipin antibody (aCL) employing a‐oxLDL ELISA. We found that no significant optical density differences existed among systemic lupus erythematosus patients, including cases with aCL and/or lupus anticoagulant positivity, before and after the addition of GPI. Our results suggest that a‐oxLDL is not an antibody to denatured GPI, but rather to oxLDL. © 1996 Wiley‐Liss, Inc.