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Paraneoplastic pemphigus in a patient with non‐Hodgkin's lymphoma
Author(s) -
Plumb Renee,
Doolittle Gary C.
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199605)52:1<58::aid-ajh10>3.0.co;2-3
Subject(s) - paraneoplastic pemphigus , medicine , lymphoma , pemphigus , dermatology , refractory (planetary science) , pathology , neoplasm , radiation therapy , pemphigus vulgaris , autoantibody , immunology , antibody , physics , astrobiology
Paraneoplastic pemphigus (PNP) is an autoimmune disorder occurring in the setting of an underlying neoplasm in which patients have polymorphous skin and mucous membrane lesions. We describe a patient with non‐Hodgkin's lymphoma who developed bullous, ulcerating lesions in an area being treated with radiation therapy. The diagnosis of PNP was confirmed by indirect immunofluorescence of the patient's serum on rat bladder. The disorder was refractory to therapy, and ultimately the patient expired. © 1996 Wiley‐Liss, Inc.