Premium
Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells
Author(s) -
Aller Cynthia Timlick,
Kucuk Omer,
Springer Georg F.,
GilmanSachs Alice
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199605)52:1<29::aid-ajh5>3.0.co;2-8
Subject(s) - immunophenotyping , chronic lymphocytic leukemia , epitope , flow cytometry , monoclonal antibody , leukemia , antigen , monoclonal , medicine , immunology , t cell , b cell , pathology , antibody , immune system
Immunophenotyping of peripheral blood lymphocytes from six patients with B‐cell chronic lymphocytic leukemia (B‐CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cytometry. Lymphocytes from all patients showed strong Tn expression as compared to normal control lymphocytes. By contrast, T antigen was not expressed. The Tn expression may be a useful diagnostic and prognostic marker for B‐CLL. © 1996 Wiley‐Liss, Inc.