Premium
Random suppression of T cells that bear specific T cell receptor Vβ sequences in adult T cell leukemia/lymphoma (ATLL) patients at each clinical stage: Carrier, smoldering, chronic, and acute
Author(s) -
Ohshima Koichi,
Suzumiya Junji,
Kikuchi Masahiro,
Takeshita Morishige,
Tashiro Kotaro,
Kimura Nobuhiro
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199605)52:1<1::aid-ajh1>3.0.co;2-z
Subject(s) - superantigen , leukemia , immunology , t cell receptor , biology , lymphoma , acute leukemia , t cell , chronic leukemia , t cell leukemia , chronic lymphocytic leukemia , virology , immune system
Human T cell leukemia virus type I (HTLV‐I) is associated with adult T cell leukemia/lymphoma (ATLL), which is well known as a T cell malignancy. In order to clarify whether HTLV‐I plays a role as a virus‐encoded superantigen in the neoplastic process, we examined the TCR Vβ families in the peripheral blood at four different clinical stages: carrier, smoldering leukemia, chronic leukemia, and acute leukemia. An increased number of CD4 T cells was found in each of the four clinical stages. However, we found neither uniform specific losses nor uniform clonal expansion of particular TCR Vβ gene families in any case from the four clinical stages. However, a suppression of the random TCR Vβ families was found. Our data did not therefore directly suggest the existence of a common superantigen model of HTLV‐I which induces an increase in CD4 T cells. The random suppression in the TCR Vβ repertoire is most likely caused by the influence of HTLV‐I neoplastic pathogenesis rather than by virus‐encoded superantigens. In the patients with acute leukemia, one or two families of the Vβ repertoires were very strongly expressed, while in chronic leukemia, no such repertoire of strong expression was observed. The immunological reaction of the hosts might thus be different between the above described groups. © 1996 Wiley‐Liss, Inc.