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Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1½‐year‐old girl: Report of a case and review of the literature
Author(s) -
Lee Margaret T.,
Nardi Michael A.,
Hu Grace,
HadziNesic Joan,
Karpatkin Margaret
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199604)51:4<307::aid-ajh10>3.0.co;2-b
Subject(s) - hypoprothrombinemia , bleeding diathesis , medicine , partial thromboplastin time , coagulation , lupus anticoagulant , prothrombin time , thromboplastin , immunology , coagulopathy , gastroenterology , thrombin time , antibody , platelet , vitamin k
Acquired inhibitors of coagulation causing bleeding manifestations are rare in children, particularly without an associated underlying disorder such as autoimmune disease. We describe an otherwise healthy 1½‐year‐old girl who had extensive spontaneous bruising and prolonged bleeding from venipuncture sites. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were prolonged, with evidence of an immediate‐acting inhibitor. Thrombin clotting time, fibrinogen, and platelets were normal. Biologic assay of factors II, V, VII, and X were all low, with increasing values at higher dilutions. However, by immunoassay and/or chromogenic assays, only factor II was reduced. An antibody which failed to neutralize prothrombin activity in vitro was detected against radiolabeled prothrombin. Coagulation studies normalized in parallel with clinical recovery and disappearance of the antibody. This case demonstrates acute hypoprothrombinemia‐lupus anticoagulant syndrome as a rare presentation of bleeding diathesis in a healthy young child. © 1996 Wiley‐Liss, Inc.