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Acute lymphoblastic leukemia with myeloperoxidase activity
Author(s) -
Wright Susan,
Chucrallah Antoine,
Chong Yap Yee,
Kantarjian Hagop,
Keating Michael,
Albitar Maher
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199602)51:2<147::aid-ajh9>3.0.co;2-y
Subject(s) - myeloperoxidase , immunophenotyping , myeloid leukemia , precursor cell , myeloid , leukemia , acute leukemia , cd33 , medicine , lymphoblastic leukemia , acute lymphocytic leukemia , cancer research , antigen , immunology , pathology , cell , biology , microbiology and biotechnology , inflammation , stem cell , biochemistry , cd34
The French‐American‐British (FAB) classification of acute leukemias is based on the light microscopic detection of myeloperoxidase (MPO) activity in blast cells. Cells with MPO activity in >3% of cells are classified as acute myeloid leukemia (AML) and usually express myeloid cell surface antigens. We describe a case of acute leukemia in which the blast cells have lymphoid morphology, ultrastructure, immunophenotype, and molecular rearrangements, but express significant amounts of MPO. We discuss the incidence, features, and outcome of MPO‐positive acute lymphoblastic leukemia (ALL). © 1996 Wiley‐Liss, Inc.