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Concurrent presentation of erythrocytic and megakaryocytic aplasia
Author(s) -
Canavan Brian F.,
Huhn Richard D.,
Kim Hugh C.,
Kosmin Martin,
Sheay Wendy,
Saidi Parvin
Publication year - 1996
Publication title -
american journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.456
H-Index - 105
eISSN - 1096-8652
pISSN - 0361-8609
DOI - 10.1002/(sici)1096-8652(199601)51:1<68::aid-ajh11>3.0.co;2-7
Subject(s) - bone marrow aplasia , aplasia , immunology , bone marrow , immune system , mechanism (biology) , stem cell , medicine , biology , cancer research , genetics , philosophy , epistemology
A case of a patient presenting with idiopathic concurrent erythrocytic and megakaryocytic aplasia is reported. The patient's response to immunosuppressive therapy and her bone marrow pathology clearly suggest an immune mechanism. Based on the lack of suppression of erythroid colony growth, several mechanisms are postulated. Well‐established molecular and genetic evidence, along with clinical observations, suggests that a relationship exists between the erythrocytic and megakaryocytic cell lines. This may be related to a common bipotential stem cell or common cell surface markers. This case provides strong clinical evidence to support this relationship. © 1996 Wiley‐Liss, Inc.