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Association between cytosolic low molecular weight phosphotyrosine‐phosphatase and malaria—a possible mechanism
Author(s) -
Bottini Egidio
Publication year - 1999
Publication title -
american journal of physical anthropology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.146
H-Index - 119
eISSN - 1096-8644
pISSN - 0002-9483
DOI - 10.1002/(sici)1096-8644(199902)108:2<241::aid-ajpa9>3.0.co;2-z
Subject(s) - cytosol , mechanism (biology) , malaria , phosphatase , microbiology and biotechnology , chemistry , association (psychology) , biochemistry , biology , phosphorylation , immunology , enzyme , psychology , philosophy , epistemology , psychotherapist
Cytosolic low molecular weight phosphotyrosine‐phosphatase shows dephosphorylating activity of the band 3 protein. Increased phosphorylation of this protein increases membrane rigidity and resistance to invasion of red blood cells by malarial parasites. This observation may explain the negative association previously reported by our group between the high activity * C allele of cytosolic low molecular weight phosphotyrosine‐phosphatase and past malarial morbidity. Am J Phys Anthropol 108:241–244, 1999. © 1998 Wiley‐Liss, Inc.