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Cu‐Catalyzed Allylic C─H Arylation of 3‐Phospholene Oxides with Triarylboroxines
Author(s) -
Li Ang,
Wu GuoJie,
Han FuShe
Publication year - 2025
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202501356
Abstract A copper‐catalyzed oxidative allylic C─H arylation of 3,4‐diaryl‐3‐phospholene 1‐oxide derivatives with triarylboroxines is presented. Under the optimized conditions, the reaction displayed a broad compatibility for both phospholene and boroxine substrates, affording 2‐monoarylated and 2,5‐diarylated phosphole compounds in high overall yield (up to 74%), with monoarylated products as major products in moderate to moderately high yields (up to 58%). The scalability of the method was demonstrated by performing the reaction at a gram‐scale level. In addition, the versatile diversification of the products was also exemplified. Consequently, the method provides a new route for the diverse synthesis of structurally novel and potentially useful 2,3,4‐triaryl‐substituted phosphole derivatives and, moreover, enriches the methodology for allylic C─H functionalization.