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A Novel Three‐Component Reaction of Halo‐Pyridines with Grignard Reagents
Author(s) -
Huang Zhiwei,
Fang LiangQi,
Li JingHua,
Wang Jian,
Cheng Dongping
Publication year - 2025
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.202405989
Abstract A novel three‐component reaction of halo‐pyridines with Grignard reagents under transition metal‐free conditions is developed. Chloro‐ and bromo‐pyridines are treated with BTC/DMAP at room temperature to form bipyridinium salts, which then react with Grignard reagents to yield three‐component coupling products. The obtained pyridines linked 1,4‐dihydropyridines may offer a good opportunity to discover new bioactive molecules.
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