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MRI detects tubulointerstitial changes in mouse models of radiation‐induced nephropathy
Author(s) -
Stabinska Julia,
Piccolo Joe,
Chhabra Anupriya,
Liatsou Ioanna,
Gabrielson Kathy,
Li Zhi,
Mohanta Zinia,
Sedaghat Farzad,
Hobbs Robert F.,
Sgouros George,
McMahon Michael T.
Publication year - 2025
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.30443
Subject(s) - histology , renal medulla , chemistry , kidney , irradiation , nuclear medicine , renal cortex , pathology , nephropathy , medulla , medicine , endocrinology , physics , diabetes mellitus , nuclear physics
Abstract Purpose We hypothesized that radiation‐induced tubulointerstitial changes in the kidney can be assessed using MRI‐based T 2 relaxation time measurements. Methods We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an α‐particle‐emitting actinium‐225 radiolabeled antibody. We compared the mean T 2 values of different renal compartments between control and external beam radiotherapy or α‐particle‐emitting actinium‐225 radiolabeled antibody–treated groups and between the two radiation‐treated groups using a Wilcoxon rank‐sum test. Results Significantly higher T 2 values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group ( p < 0.05). In addition, these changes in T 2 were observed before any changes in serum parameters, animal body weight, and kidney volume occurred. Conclusion T 2 mapping is sensitive to radiation‐induced tubulointerstitial changes in the kidney.