Light‐Activated Pharmacological Tools for Exploring the Cholinergic System | Zendy

Colleoni Alessio | Zendy; Galli Giulia | Zendy; Dallanoce Clelia | Zendy; De Amici Marco | Zendy; Gorostiza Pau | Zendy; Matera Carlo | Zendy

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Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Author(s) -

Colleoni Alessio,

Galli Giulia,

Dallanoce Clelia,

De Amici Marco,

Gorostiza Pau,

Matera Carlo

Publication year - 2025

Publication title -

medicinal research reviews

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.868

H-Index - 130

eISSN - 1098-1128

pISSN - 0198-6325

DOI - 10.1002/med.22108

Subject(s) - cholinergic , cholinergic system , neuroscience , nicotinic agonist , acetylcholine , cholinesterase , muscarinic acetylcholine receptor , mediator , computer science , pharmacology , biology , receptor , biochemistry , microbiology and biotechnology

ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to overcome the limitations of traditional drugs using photocleavable or photoswitchable ligands and spatiotemporal patterns of illumination. Spanning from muscarinic and nicotinic modulators to cholinesterase inhibitors, this review explores the development and application of light‐activated compounds as tools for unraveling the role of cholinergic signaling in both physiological and pathological contexts, while also paving the way for innovative phototherapeutic approaches.

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