Front Cover: Multigram Synthesis of 3‐Azabicyclo[3.1.1]heptane Derivatives Including Bicyclic Thalidomide Analogs (Eur. J. Org. Chem. 17/2025)

The Front Cover shows a wizard casting a conformational restriction spell onto a molecule of thalidomide. The magical transformation leads to a 3‐azabicyclo[3.1.1]heptane derivative—a promising scaffold for potential drug‐discovery applications. In their Research Article (DOI: 10.1002/ejoc.202400938 ), O. O. Grygorenko and co‐authors describe a multigram synthetic approach toward such molecules (with almost no magic involved). In particular, a series of 1‐substituted 3‐azabicyclo[3.1.1]heptanes, that is, monoprotected diamine building blocks, thalidomide analogs, and troxipide mimetics, were prepared with high efficiency. Artwork by Vitalii Boklashchuk.