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Transformation of Anilines to 1‐Azaspiro[4.5]decanes via Dearomatization and Palladium‐Catalyzed aza‐[3+2] Cycloaddition with Vinylcyclopropanes
Author(s) -
Xu Tingxuan,
Hu Jinhao,
He Qiuqin,
Fan Renhua
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202500175
Abstract A method to transform anilines to 1‐azaspiro[4.5]decanes via oxidative dearomatization and palladium‐catalyzed aza‐[3+2] cycloaddition with vinylcyclopropanes was reported. The reaction showed broad substrate compatibility. Moreover, an asymmetric version of the cycloaddition was preliminarily explored.

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