Premium
Synthesis of C2‐Silylated Indoles and Indolines Enabled by Iridium‐Catalyzed Silylation of Indolines with Hydrosilanes
Author(s) -
Wang Lei,
Tang Xinni,
Sun Hui,
Hu Wenjie,
Xu LiWen,
Yang Lei
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202500166
Subject(s) - chemistry , iridium , silylation , catalysis , organic chemistry , combinatorial chemistry
An efficient iridium‐catalyzed one‐pot protocol is reported for the synthesis of C2‐silylated indoles from indolines and hydrosilanes. Mechanistic investigations suggest that the transformation proceeds through a tandem dehydrogenation/C–H silylation pathway. Furthermore, an example of iridium‐catalyzed direct C2‐selective C( sp 3 )–H silylation of indolines is also disclosed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom