ortho ‐Hydroxylation of N ‐Nitrosoanilines Using Palladium Acetate and TBHP

Abstract Herein, we report a Pd(II)‐catalyzed highly regiospecific ortho ‐hydroxylation of N ‐nitrosoanilines utilizing tert ‐butyl hydroperoxide (TBHP) as the hydroxylating source. The reaction proceeds through N ‐nitroso group directed C−H activation and subsequent hydroxylation at the ortho ‐position. The protocol provides a mild, operationally straightforward, and high‐yielding transformation, offering a valuable tool for the construction of ortho ‐hydroxylated aniline derivatives, which are important intermediates in pharmaceutical and materials chemistry.