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Tandem Friedel‐Crafts Alkylation/Lactonization for γ‐Lactone
Author(s) -
Wu Fufang,
Liu Miao,
Jia Hao,
Zhang Xueyin,
Shen Xiaobao,
Zhai Hongbin
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202500044
Subject(s) - friedel–crafts reaction , chemistry , tandem , alkylation , lactone , organic chemistry , catalysis , materials science , composite material
Abstract The lactonization of C(sp 3 )−H bonds from simple, readily available materials remains a significant challenge in organic synthesis. In this study, we present a tandem Friedel‐Crafts Alkylation /Lactonization reaction using aromatic compounds and cyclo‐anhydrides as raw materials to obtain γ‐lactones under metal‐free conditions. This method offers operational simplicity, broad substrate scope, and high synthetic efficiency. Furthermore, the gram scale experiment of this reaction had been conducted, and the synthesis of natural product Cytosporanone A was achieved using this method.