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Recent Developments in C−H Functionalization and Annulation of 2‐Aryl‐Quinazolinones and 3‐Aryl‐Quinazolinones via Site Selective Transformations
Author(s) -
Mahato Karuna,
Shrestha Divya,
Roy Prasanta,
Lee Seung Woo
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202500034
Subject(s) - annulation , chemistry , surface modification , aryl , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , alkyl
Abstract Quinazolinone is a crucial scaffold in numerous natural compounds, as well as in biologically active and functional materials. Consequently, various synthetic methods have been developed to transform quinazolinone and its derivatives. Site selective C−H bond functionalization and annulation of the 2‐aryl‐quinazolinones and 3‐aryl‐quinazolinones skeleton through transition‐metal catalysis offer an efficient approach to obtain diverse substituted nitrogen‐containing heterocyclic frameworks. This review summarizes recent reports on transition‐metal catalyzed site selective transformations of 2‐aryl‐quinazolinone and 3‐aryl‐quinazolinones through C−H functionalization and annulation reactions.