High Regio‐ and Chemoselectivity [2 + 4] Tandem Annulations Catalyzed by CsF to the Synthesis of 4‐Quinolones under Continuous‐Flow Reactor | Zendy

Wang Zhuoyu | Zendy; Li Junjie | Zendy; Li Weiqiang | Zendy; Liu Rong | Zendy; Zhang Chunyan | Zendy; Gao Sirong | Zendy; Liu Teng | Zendy; Huang Chao | Zendy

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High Regio‐ and Chemoselectivity [2 + 4] Tandem Annulations Catalyzed by CsF to the Synthesis of 4‐Quinolones under Continuous‐Flow Reactor

Author(s) -

Wang Zhuoyu,

Li Junjie,

Li Weiqiang,

Liu Rong,

Zhang Chunyan,

Gao Sirong,

Liu Teng,

Huang Chao

Publication year - 2025

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.202500016

Subject(s) - chemoselectivity , chemistry , tandem , catalysis , continuous flow , combinatorial chemistry , regioselectivity , organic chemistry , flow chemistry , biochemical engineering , materials science , engineering , composite material

A high regio‐ and chemoselectivity route to the synthesis of 4‐quinolone derivatives involving a CsF‐catalyzed [2 + 4] tandem annulations under continuous‐flow reactor has been developed. This practical and concise protocol between aryne precursors and β ‐enamino diesters provided a range of structurally diverse 4‐quinolones (28 examples) in good to excellent yields. The characteristics of this continuous‐flow are safe operation, high regio‐ and chemoselectivity in a short time. This approach can enrich and develop aryne chemistry, and might provide new opportunities for the discovery of 4‐quinolone drugs.

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