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Multicomponent Reactions Mediated by Supramolecular Containers
Author(s) -
Zhou Xiaojuan,
Ma XinChao,
Hong Zhiyang,
Zhang JingYi,
Wang Rui
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202500008
Abstract Multicomponent reactions (MCRs) have drawn great attention due to their various significant advantages including highly efficient, environment‐friendly, and atom‐economic. Developing more efficient and selective MCRs is of great significance to construct chemical libraries of potential functional compounds. On the other hand, supramolecular containers have been successfully applied as novel nanoreactors to mediate diverse organic transformations, and MCRs are included. In this review, examples of supramolecular container mediated MCRs have been summarized. The supramolecular containers include β‐cyclodextrin (β‐CD), γ‐cyclodextrin (γ‐CD), calix[4]arene, self‐assembled Ga(III)‐ligand tetrahedral coordination cage ([Ga 4 L 6 ] 12− ), and decanuclear 3d–4f lanthanide metal‐organic cage ([Zn 2 Yb 8 (L) 8 Cl 2 ] 2+ ). The MCRs cover Hantzsch, Biginelli, aza‐Darzens, Strecker, and other three‐component reactions. Effects of the supramolecular containers have been illustrated and prospects for the future are also provided.