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Visible Light‐Driven E ‐Selective Semihydrogenation of Alkynes and Their Application in the Treatment of Glioblastoma Multiforme
Author(s) -
Yang Huihui,
Wang Xianglong,
Chen Siqi,
Li Shutang,
Li Baohu,
Fan Yanrui,
He Haoze,
Lin Zhou,
Yang Jinfei
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202401370
Subject(s) - chemistry , glioblastoma , nanotechnology , cancer research , biology , materials science
A visible light‐driven E ‐selective semihydrogenation scheme of alkyne compounds is developed for designing and synthesizing glioblastoma multiforme inhibitors. Herein, room‐temperature semihydrogenation reactions of various alkyne compounds are successfully achieved under the irradiation of white light. The representative reaction mechanism is decoded through theoretical calculations and deuteration experiments, revealing the critical roles played by [Ir(Cp‐Me 5 )Cl 2 ] 2 , PdCl 2 , DPPE and TEOA as photosensitizer, catalyst, ligand, and electron donor, respectively. This method exhibits excellent E ‐selectivity and broad functional group compatibility and demonstrates its practical value by producing pinosylvin and its derivatives with strong inhibitory effects on U87 cells.