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Recent Developments for the Ring Opening of Pyrrolidines and Unstrained Cyclic Amines via C−N Bond Cleavage
Author(s) -
Ota Eisuke,
Yamaguchi Junichiro
Publication year - 2025
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.202401322
Subject(s) - chemistry , cyclic amines , cleavage (geology) , bond cleavage , ring (chemistry) , stereochemistry , combinatorial chemistry , organic chemistry , amine gas treating , catalysis , geotechnical engineering , fracture (geology) , engineering
Abstract In recent years, the deconstructive transformation of unstrained cyclic amines via C−N bond cleavage has emerged as a powerful strategy for expanding chemical space and facilitating the synthesis of structurally diverse molecules. Notably, advancements in the C−N bond cleavage of pyrrolidine and other unstrained cyclic amines have highlighted the significant potential of this approach in modern organic synthesis. This concept reviews recent developments in the C−N bond cleavage reaction, with a primary focus on pyrrolidines, while also exploring broader progress in related systems.