Chirality Communication and Transmission Within Palladium(II) Quadruple‐Stranded Helicates

Abstract Over the past few decades, chirality in discrete metallosupramolecular architectures has garnered significant attention. This concept offers a comprehensive overview of chiral metal‐organic coordination‐driven structures, particularly those of the M₂L₄ type. The focus is on recent advancements in quadruple‐stranded metallosupramolecular complexes, where chirality emerges not from a specific arrangement of ligands around metal centers, but rather from ligand twisting and inter‐ligand interactions. Special emphasis is placed on homochiral metallo‐assemblies, exploring chiral intra‐ and inter‐molecular transmission and chirality induction via guest encapsulation. We hope this concept will be of interest to researchers aiming to design novel, intricate homochiral metallosupramolecular structures with increased complexity and enhanced functional potential.