Cover Feature: Ancestral Sequence Reconstruction and Comprehensive Computational Simulations Unmask an Efficient PET Hydrolase with the Wobbled Catalytic Triad (ChemSusChem 10/2025)

The Cover Feature illustrates how enzymes, originating from ancient harsh environments, possess the ability to hydrolyze bis(2‐hydroxyethyl)terephthalate (BHET), a key intermediate in the degradation of PET, prevalent in modern society. The ASR‐PETase was constructed by using ancient sequence reconstruction technology, enabling the hydrolysis of BHET into terephthalic acid, which accelerates PET recycling. The highlighted residues within ASR‐PETase emphasize the ancient mechanisms with a wobbled catalytic triad that facilitate the hydrolysis. More information can be found in the Research Article by X. Li and co‐workers (DOI: 10.1002/cssc.202402614).