Ergosterol and Lanosterol Derivatives: Synthesis and Possible Biomedical Applications | Zendy

StefaniakSkorupa Joanna | Zendy; Milewska Maria J. | Zendy

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Ergosterol and Lanosterol Derivatives: Synthesis and Possible Biomedical Applications

Author(s) -

StefaniakSkorupa Joanna,

Milewska Maria J.

Publication year - 2025

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.202400948

Subject(s) - lanosterol , ergosterol , antifungal , chemistry , antimicrobial , biochemistry , sterol , stereochemistry , organic chemistry , biology , microbiology and biotechnology , cholesterol

Abstract Lanosterol is the crucial intermediate in ergosterol biosynthesis in fungi. A number of derivatives of natural or synthetic origin of these sterols are portrayed in this review. For the synthetic derivatives, strategies of their syntheses are presented. Biological activities of lanosterol and ergosterol derivatives include antimicrobial, especially antifungal action, anticancer and antiviral effects but also anti‐inflammatory and anti‐allergic potential. The most promising seems to be the anticancer potential of peroxides, epoxides, and keto‐ derivatives of both sterols.

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