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A Sydnonimine‐based Click‐and‐Release Approach to Cyclic Products
Author(s) -
Force Guillaume,
Feng Minghao,
Audisio Davide,
Thuéry Pierre,
Schulz Emmanuelle,
Taran Frédéric
Publication year - 2025
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202500860
Abstract Herein, we report a general, efficient, and practical methodology for the macrocyclization of compounds based on the combination of a Cu‐catalyzed click‐and‐release reaction and a hydrophobic tag. The procedure allows the preparation of cyclic products of different sizes and with various functionalities without the need of purification.

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