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Efficient and Selective Transformations of α‐Keto Esters into α‐Arylated α‐Hydroxy Esters Using Continuous‐Flow System
Author(s) -
Qenawy Mohmmad S.,
Okamoto Kazuhiro,
Nagaki Aiichiro
Publication year - 2025
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202500299
Subject(s) - microreactor , reagent , selectivity , chemistry , steric effects , yield (engineering) , flow chemistry , electrophile , combinatorial chemistry , mixing (physics) , continuous flow , organic chemistry , materials science , biochemical engineering , catalysis , engineering , physics , quantum mechanics , metallurgy
Abstract This research explores the selective reactions of organolithium reagents with α‐keto esters using a flow microreactor system. The study highlights the influence of precise temperature control and rapid mixing on enhancing reaction yield and selectivity. By optimizing conditions for aryllithium reagents bearing electrophilic functional groups and α‐keto esters, the system demonstrated superior performance over traditional batch methods. This method efficiently minimized byproduct formation, providing high yields and excellent selectivity for sterically hindered substrates. The flow microreactor thus offers an innovative platform for complex organometallic transformations.