Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups | Zendy

Atsugi Takahiro | Zendy; Fujiwara Shoji | Zendy; Kondo Jiro | Zendy; Ono Akira | Zendy

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Synthesis and Metal‐Ion Binding Properties of Duplexes Containing Thymine Analogs with 1,2‐Diamine Groups

Author(s) -

Atsugi Takahiro,

Fujiwara Shoji,

Kondo Jiro,

Ono Akira

Publication year - 2025

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.202500017

Subject(s) - metal ions in aqueous solution , oligonucleotide , chemistry , thymine , metal , duplex (building) , diamine , stereochemistry , base pair , ion , crystallography , polymer chemistry , combinatorial chemistry , dna , organic chemistry , biochemistry

Thymidine analogue with a 1,2‐diamino side chain at the 3N position is synthesized and converted into an amidite unit for oligonucleotide synthesis. It is used for preparing oligonucleotides containing a 1,2‐diamino side chain as X residue. Thermal denaturation studies are performed on a duplex containing an X–X pair in the presence and absence of metal ions. Among various metal ions used in this research, Cd(II), Co(II), Cu(II), Ni(II), and Zn(II) ions increased the duplex stability. The results prove the new strategy to design metallo‐base pairs containing various metal ions.

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