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Antimicrobial Piano‐Stool and Polypyridyl Ru(II) Complexes with Thiazolhidrazinylidene‐Chroman‐2,4‐Dione: Tautomerism, Membrane Disruption, and Electron Transport Interference
Author(s) -
Rahmani Fatlinda,
Demirci Gozde,
Cortat Youri,
Crochet Aurélien,
Zobi Fabio
Publication year - 2025
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202401025
A library of (η 6 ‐p‐cymene)Ru(II) and Ru(II) bis ‐bpy complexes bearing thiazolhidrazinylidene‐chroman‐2,4‐dione was synthesized, characterized, and the molecules are evaluated for their antibacterial activity and cytotoxicity. From this library, several compounds are identified as being active against Methicillin‐resistant Staphylococcus aureus and Methicillin‐sensitive S. aureus . A polypyridyl complex showed a noteworthy minimum inhibitor concentration of 3.1 μ m and no toxicity in healthy eukaryotic cells with a therapeutic index of >32. Active complexes appear to exert their antibiotic activity by affecting both the permeabilization of the bacterial membrane and/or the electron transport chain.