Lanthanide‐Doped Upconversion Nanoparticles for Single‐Particle Imaging | Zendy

Ling Huan | Zendy; Zhang Wenrui | Zendy; Zhang Yunxiang | Zendy; Shen Jie | Zendy; Liu Qian | Zendy

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Lanthanide‐Doped Upconversion Nanoparticles for Single‐Particle Imaging

Author(s) -

Ling Huan,

Zhang Wenrui,

Zhang Yunxiang,

Shen Jie,

Liu Qian

Publication year - 2025

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.202400942

Subject(s) - nanotechnology , lanthanide , photon upconversion , nanoparticle , brightness , particle (ecology) , materials science , quenching (fluorescence) , fluorescence lifetime imaging microscopy , fluorescence , doping , computer science , chemistry , physics , optics , optoelectronics , ion , oceanography , organic chemistry , geology

Lanthanide‐doped upconversion nanoparticles (UCNPs) have recently demonstrated great promise in single‐particle imaging (SPI) due to their exceptional photostability and minimal background fluorescence. However, their limited brightness has posed a significant barrier to wider adoption in SPI applications. This review highlights recent advances in applying UCNPs for SPI, focusing on strategies to enhance their brightness and reduce quenching effects in aqueous environments. Additionally, it summarizes the latest progress in using UCNPs for single‐particle tracking and super‐resolution imaging, underscoring their potential in biomedical research. Finally, the review outlines current challenges and future directions in this field.

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