Ferric Chloride Mediated Dearomative Spirocyclization of Biaryl Ynones: Synthesis of 3,3‐Spiroindanones | Zendy

Jaiswal Gaurav | Zendy; Chandra Pan Subhas | Zendy

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Ferric Chloride Mediated Dearomative Spirocyclization of Biaryl Ynones: Synthesis of 3,3‐Spiroindanones

Author(s) -

Jaiswal Gaurav,

Chandra Pan Subhas

Publication year - 2025

Publication title -

chemistry – an asian journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.18

H-Index - 106

eISSN - 1861-471X

pISSN - 1861-4728

DOI - 10.1002/asia.202401694

Subject(s) - ferric , regioselectivity , chloride , ring (chemistry) , chemistry , scope (computer science) , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , computer science , programming language

Abstract Ferric chloride mediated dearomative spirocyclization of biaryl ynones for the synthesis of new series of densely functionalized 3,3‐spiroindanone derivatives has been reported. This study is the first to describe the regioselective synthesis of a five‐membered ring from biaryl ynones. The scope of the reaction is broad and the spirocyclic products were obtained in moderate to good yields (up to 87 %) and with high stereoselectivities.

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