Bio‐Based Poly(γ‐Glutamic Acid) Hydrogels for the Controlled Release of Neomycin Sulfate | Zendy

BorgesHernández Eleany | Zendy; RodríguezFelix Dora Evelia | Zendy; GarmendíaDiago Yaniris | Zendy; FloresLeón José Ramón | Zendy; CastilloCastro Teresa | Zendy; QuirozCastillo Jesús Manuel | Zendy; EncinasEncinas José Carmelo | Zendy; AlvaradoIbarra Juana | Zendy; GarcíaSifuentes Celia Olivia | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Bio‐Based Poly(γ‐Glutamic Acid) Hydrogels for the Controlled Release of Neomycin Sulfate

Author(s) -

BorgesHernández Eleany,

RodríguezFelix Dora Evelia,

GarmendíaDiago Yaniris,

FloresLeón José Ramón,

CastilloCastro Teresa,

QuirozCastillo Jesús Manuel,

EncinasEncinas José Carmelo,

AlvaradoIbarra Juana,

GarcíaSifuentes Celia Olivia

Publication year - 2025

Publication title -

journal of applied polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.575

H-Index - 166

eISSN - 1097-4628

pISSN - 0021-8995

DOI - 10.1002/app.56927

Subject(s) - self healing hydrogels , neomycin , sulfate , chemistry , controlled release , glutamic acid , polymer chemistry , materials science , nuclear chemistry , biochemistry , nanotechnology , organic chemistry , amino acid , antibiotics

ABSTRACT The use of biopolymer‐based hydrogels represents a promising alternative for achieving controlled drug release. In this study, poly(γ‐glutamic acid) hydrogels loaded with neomycin sulfate were obtained. Characterization of drug‐loaded hydrogels was conducted using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT‐IR), and Thermogravimetric Analysis (TGA), confirming the presence of the drug within the polymer matrix and elucidating interactions between neomycin sulfate and polymer chains. The controlled release of neomycin sulfate was evaluated under various pH and temperature conditions. Data fitting the Korsmeyer‐Peppas model indicated an “anomalous” diffusion process. Cytotoxicity tests on the L929 cell line revealed biocompatibility at concentrations of 3.125, 6.250, 12.5, and 25 mg/mL. Therefore, this work indicates that poly(γ‐glutamic acid)‐based hydrogels are biocompatible and highly effective for controlled drug release.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research