Premium
One‐Component Ionizable Amphiphilic Janus Dendrimers for Targeted mRNA Delivery
Author(s) -
Zhu Pengyu,
Li Yongsheng,
Zhang Dapeng
Publication year - 2025
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202505304
Abstract mRNA nanomedicine represents a new generation of therapeutics. However, how to deliver mRNA to the desired organs and cells effectively remains challenging. Common mRNA delivery vectors include viral and nonviral types such as four‐component lipid nanoparticles (LNPs), polymer‐based nanoparticles, lipid‐polymer hybrid nanoparticles, and so on. One‐component ionizable amphiphilic Janus dendrimers (IAJDs), are an emerging type of mRNA delivery vehicle displaying good stability and high delivery efficiency. In this review, we comprehensively present the design, synthesis, and mRNA delivery properties of IAJDs, with particular focus on the relationship between their molecular structures and organ targeted delivery properties. Other representative types of dendrimers for RNA delivery are also reviewed. Overall, this review summarizes the recent research progress on IAJDs systematically, aiming to guide the development of more efficient mRNA delivery platforms and next‐generation mRNA nanomedicines.