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Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters
Author(s) -
Aldhous Timothy P.,
Chung Raymond,
Hassan Abbas,
Dalling Andrew G.,
Cooper Phillippa,
Grélaud Simon,
Mudd Richard J.,
Feron Lyman J.,
Kemmitt Paul D.,
Bower John F.
Publication year - 2025
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202502569
Subject(s) - stereocenter , enantioselective synthesis , benzamide , ferrocene , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , electrode , electrochemistry
Abstract Ir‐systems modified with ferrocene‐based homochiral diphosphonite ligands, prepared from functionalized SPINOL derivatives, promote benzamide‐directed hydroarylative cross‐couplings involving minimally activated alkenes. The processes are highly branched selective and enantioselective. Accordingly, tertiary benzylic stereocenters are generated under byproduct‐free conditions. This contrast with conventional cross‐coupling approaches, which are less step and atom economical. Preliminary results show that the process extends to the formation of quaternary benzylic stereocenters.