Stability and Mitochondrial Localization of a Highly Cytotoxic Organogold(III) Complex with Diphosphine Ancillary Ligand in Lung Cancer Cells | Zendy

Blommaert Hester | Zendy; Soep Clément | Zendy; Remadna Edwyn | Zendy; Dossmann Héloïse | Zendy; Salomé Murielle | Zendy; Proux Olivier | Zendy; Kieffer Isabelle | Zendy; Hazemann JeanLouis | Zendy; Bohic Sylvain | Zendy; Salmain Michèle | Zendy; Bertrand Benoît | Zendy

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Stability and Mitochondrial Localization of a Highly Cytotoxic Organogold(III) Complex with Diphosphine Ancillary Ligand in Lung Cancer Cells

Author(s) -

Blommaert Hester,

Soep Clément,

Remadna Edwyn,

Dossmann Héloïse,

Salomé Murielle,

Proux Olivier,

Kieffer Isabelle,

Hazemann JeanLouis,

Bohic Sylvain,

Salmain Michèle,

Bertrand Benoît

Publication year - 2025

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.202422763

Subject(s) - chemistry , ligand (biochemistry) , reactivity (psychology) , fluorescence , cationic polymerization , confocal microscopy , chemical stability , x ray absorption spectroscopy , crystallography , stereochemistry , absorption spectroscopy , polymer chemistry , biochemistry , organic chemistry , biology , medicine , receptor , physics , alternative medicine , pathology , quantum mechanics , microbiology and biotechnology

Abstract We present a comprehensive study on the chemical reactivity in the gas phase, with amino acids and peptides, and in the cell, the anticancer activity and localization of a series of seven cationic biphenyl gold(III) complexes with aryl, alkyl, and chiral diphosphine ancillary ligands. Despite some structural differences, all the complexes similarly featured high stability toward reduction or ligand exchange in cell‐free conditions. The biphenyl Au(III) complex including the 1,2‐diphenylphosphinoethane (dppe) ligand manifested the same high stability in a cellular setting, as attested by a combination of cryo‐Synchrotron Radiation‐X‐Ray Fluorescence (cryo‐SR‐XRF) nano‐imaging and cryo‐Synchrotron Radiation‐X‐ray Absorption Spectroscopy (cryo‐SR‐XAS) measurements. Tandem cryo‐SR‐XRF elemental mapping and confocal fluorescence microscopy demonstrated the selective accumulation of the dppe complex in mitochondria. This represents the first study of the speciation and distribution of an organogold(III) complex in cancer cells.

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