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Inside Front Cover: Enzyme‐Activated Orthogonal Proteolysis Chimeras for Tumor Microenvironment‐Responsive Immunomodulation (Angew. Chem. 22/2025)
Author(s) -
Sun Caixia,
Liu Songhan,
Lau Jun Wei,
Yang Hanyu,
Chen Yun,
Xing Bengang
Publication year - 2025
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.202510013
Novel tumor microenvironment‐responsive enzyme‐activated clickable PROTACs, termed as ENCTACs, are presented by Bengang Xing et al. in their Research Article ( e202423057 ). Such ENCTACs enable selective formation of heterobifunctional degraders to disrupt BRD4 in tumor, effectively downregulating PD−L1 for immunotherapy. The cover illustration depicts fragments conjugation after enzyme reaction, realizing protein intervention and activating the antitumoral immune system.